Table 3 Comparison of the efficacy of atorvastatin and rivaroxaban on IL-6, CRP, TF, F1 + 2 and D-dimer levels
|  | Atorvastatin (n = 42) | Rivaroxaban (n = 44) | p | ||
|---|---|---|---|---|---|
Mean ± SD | Median (Min-max) | Mean ± SD | Median (Min-max) | ||
IL-6 Levels (pg/mL) | |||||
Pretreatment | 92,06 ± 131,74 | 43,10 (1,80–506,50) | 70,34 ± 111,11 | 18,20 (0,10–464,50) | 0,066†|
Day 30 | 85,87 ± 144,57 | 25,60 (1,80–506,50) | 77,35 ± 121,86 | 21,95 (0,40–491,50) | 0,816†|
Delta 1 | 6,19 ± 78,83 | 1,50 (-396,20–196,80) | -7,01 ± 85,68 | -0,15 (-288,40–213,60) | 0,071†|
Day 60 | 103,68 ± 165,00 | 28,00 (2,70–506,50) | 79,32 ± 122,58 | 22,65 (0,60–491,50) | 0,360†|
Delta 2 | -11,62 ± 94,52 | 0,30 (-396,20–100,70) | -8,97 ± 88,87 | -0,30 (-288,40–282,40) | 0,101†|
Day 90 | 102,82 ± 165,17 | 28,60 (2,30–506,50) | 81,17 ± 121,89 | 24,15 (0,40–491,50) | 0,402†|
Delta 3 | -10,76 ± 118,13 | 0,10 (-419,20–247,10) | -10,83 ± 89,45 | 0,00 (-288,40–285,00) | 0,089†|
CRP Levels (mg/dL) | |||||
Pretreatment | 5,20 ± 6,05 | 3,04 (0,08–27,62) | 6,08 ± 7,91 | 2,71 (0,03–31,11) | 0,846†|
Day 30 | 4,06 ± 5,31 | 1,31 (0,02–19,07) | 5,73 ± 7,83 | 1,52 (0,01–31,11) | 0,540†|
Delta 1 | 1,14 ± 5,34 | 0,14 (-11,07–27,35) | 0,35 ± 4,65 | 0,08 (-19,35 − 13,37) | 0,526†|
Day 60 | 5,75 ± 7,06 | 2,49 (0,02–27,09) | 6,50 ± 8,34 | 2,19 (0,04–31,11) | 0,876†|
Delta 2 | -0,56 ± 7,41 | 0,00 (-21,52 − 27,52) | -0,42 ± 5,92 | 0,05 (-20,94 − 13,37) | 0,555†|
Day 90 | 5,96 ± 8,32 | 2,75 (0,04–40,06) | 6,61 ± 8,33 | 1,77 (0,02–31,11) | 0,907†|
Delta 3 | -0,76 ± 8,80 | 0,00 (-39,00–27,08) | -0,54 ± 5,93 | 0,02 (-20,94 − 13,37) | 0,768†|
TF Levels (pg/ml) | |||||
Pretreatment | 76,90 ± 103,83 | 21,00 (1,40–329,30) | 76,61 ± 96,66 | 31,00 (1,20–360,70) | 0,935†|
Day 30 | 54,36 ± 80,12 | 16,65 (1,20–329,30) | 67,74 ± 88,30 | 37,85 (1,30–342,90) | 0,323†|
Delta 1 | 22,54 ± 56,98 | 0,10 (-34,40–243,40) | 8,85 ± 45,77 | 0,00 (-142,60–185,70) | 0,286†|
Day 60 | 59,33 ± 79,78 | 25,65 (1,5-329,30) | 74,48 ± 90,50 | 47,50 (0,60–365,60) | 0,306†|
Delta 2 | 17,57 ± 73,13 | 0,00 (-103,40–265,40) | 2,11 ± 67,72 | 0,00 (-273,70–249,10) | 0,781†|
Day 90 | 66,53 ± 79,30 | 33,55 (1,30–329,30) | 78,80 ± 95,85 | 37,70 (1,50–365,60) | 0,622†|
Delta 3 | 10,37 ± 64,17 | 0,00 (-97,80–203,30) | -2,21 ± 71,87 | 0,00 (-273,70–204,30) | 0,504†|
F1 + 2 Levels (pg/mL) | |||||
Pretreatment | 4494,55 ± 1896,70 | 5119,00 (585–8993) | 3620,52 ± 1780,01 | 3674,50 (363–6436) | 0,030‡ |
Day 30 | 3814,40 ± 2044,99 | 3955,00 (193–8993) | 3215,66 ± 1860,38 | 3022,00 (237–8445) | 0,159‡ |
Delta 1 | 680,14 ± 1469,40 | 0,00 (-2418-4328) | 404,86 ± 1923,82 | 2,00 (-4779-4994) | 0,459‡ |
Day 60 | 4092,19 ± 1773,52 | 4062,50 (69-8993) | 3462,18 ± 1822,03 | 3233,50 (353–8445) | 0,108‡ |
Delta 2 | 402,35 ± 1394,04 | 0,00 (-2551-3790) | 158,34 ± 1694,50 | 0,00 (-4779-4084) | 0,729†|
Day 90 | 4273,95 ± 1604,51 | 4205,00 (417–8993) | 3529,00 ± 1835,69 | 3570,50 (82-8445) | 0,049‡ |
Delta 3 | 220,60 ± 1380,76 | 0,00 (-3072-4012) | 91,52 ± 1894,42 | 7,50 (-4779-3449) | 0,890†|
D-Dimer Levels(ug/L) | |||||
Pretreatment | 3167,62 ± 3827,20 | 1930,00 (270-19200) | 3380,68 ± 3604,99 | 2255,00 (290-20000) | 0,569†|
Day 30 | 2277,76 ± 3252,08 | 1450,00 (270-19200) | 2878,64 ± 4165,22 | 1370,00 (270-20000) | 0,863†|
Delta 1 | 889,86 ± 2289,68 | 260,00 (-1910-12730) | 502,05 ± 2881,72 | 135,00 (-9040-9730) | 0,764†|
Day 60 | 2544,29 ± 3396,72 | 1330,00 (270-19200) | 2845,36 ± 3564,05 | 1345,00 (270-15860) | 0,866†|
Delta 2 | 623,33 ± 2342,45 | 150,00 (-5070-11010) | 535,32 ± 3212,83 | 220,00 (-9040-9910) | 0,934†|
Day 90 | 2475,45 ± 3283,09 | 1685,00 (190-19200) | 3030,59 ± 4190,23 | 1428,00 (270-20000) | 0,945†|
Delta 3 | 692,17 ± 2526,04 | 125,00 (-4590-13320) | 350,09 ± 4570,87 | 145,00 (-18820-12730) | 0,825†|