A retrospective cohort analysis of plasma TAT level trends and adverse pregnancy outcomes in early pregnancy patients with newly diagnosed VTE

Table 3 Linear and non-linear associations between TAT levels and risk of abnormal pregnancy

Models and Parameters	TATp1	TATp2	TATp2-1
Linear Model
OR (95% CI)	0.97 (0.84, 1.13)	0.66 (0.53, 0.83)	0.62 (0.47, 0.80)
P-value	0.719	0.0003	0.0004
Non-linear Model
Threshold point (K)	8.94	15.82	-2.87
Below threshold
OR (95% CI)	0.59 (0.29, 1.19)	0.68 (0.54, 0.86)	1.74 (0.82, 3.71)
P-value	0.141	0.001	0.149
Above threshold
OR (95% CI)	1.11 (0.88, 1.41)	NA	0.37 (0.22, 0.63)
P-value	0.375	0.995	0.0002
LR test P-value	0.131	0.358	0.004

TATp1: Initial measurement was performed after VTE identified in first trimester, TATp2: second measurement was conducted during second trimester. TATp2-1: TAT change between TATp2 and TATp1.OR: Odds ratio; CI: Confidence interval; NA: Not applicable; LR: Likelihood ratio
All models were adjusted for age, education, number of pregnancies, number of births, BMI, delivery methods, abnormal fetal position, gestational diabetes, gestational hypertension, pre-eclampsia, uterine fibroids, assisted reproduction, thyroid diseases, and thrombophilia

ISSN: 1477-9560