A retrospective cohort analysis of plasma TAT level trends and adverse pregnancy outcomes in early pregnancy patients with newly diagnosed VTE

Table 4 Results of subgroup analysis and interaction analysis

Subgroups	N	TATp1 (OR,95%CI)	TATp2 (OR,95%CI)	TATp2-1 (OR,95%CI)
Age groups		P(interaction) = 0.902	P(interaction) = 0.196	P(interaction) = 0.203
≤ 35 years	60	0.97 (0.80, 1.18)	0.58 (0.41, 0.82)**	0.62 (0.45, 0.86)**
> 35 years	29	0.89 (0.33, 2.44)	0.80 (0.58, 1.10)	0.83 (0.58, 1.18)
Thrombophilia status		P(interaction) = 0.220	P(interaction) = 0.052	P(interaction) = 0.392
No	63	0.95 (0.79, 1.15)	0.75 (0.61, 0.93)**	0.70 (0.54, 0.91)**
Yes	26	0.83 (0.62, 1.11)	0.46 (0.26, 0.82)**	0.56 (0.33, 0.93)*
BMI categories		P(interaction) = 0.640	P(interaction) = 0.360	P(interaction) = 0.712
≤ 26 kg/m²	38	0.90 (0.69, 1.19)	0.62 (0.44, 0.86)**	0.64 (0.46, 0.89)**
> 26 kg/m²	51	1.01 (0.81, 1.27)	0.74 (0.58, 0.94)*	0.69 (0.51, 0.94)*
Overall effect	89	0.96 (0.83, 1.11)	0.69 (0.57, 0.85)***	0.67 (0.53, 0.84)***

*P < 0.05, **P < 0.01, ***P < 0.001
TATp1: Initial measurement was performed after VTE identified in first trimester, TATp2: second measurement was conducted during second trimester. TATp2-1: TAT change between TATp2 and TATp1
All models were adjusted for age, education, number of pregnancies, number of births, BMI, delivery methods, abnormal fetal position, gestational diabetes, gestational hypertension, pre-eclampsia, uterine fibroids, assisted reproduction, thyroid diseases, and thrombophilia (except when used as stratification variable)

ISSN: 1477-9560