Association of initial national early warning score with clinical deterioration in pulmonary embolism

Thrombosis Journal

Table 3 Prediction metrics of NEWS2 cut-offs for clinical deterioration (primary outcome)*

Variable	Sensitivity	Specificity	PPV	NPV	AUC	OR
NEWS2 ≥ 3	0.87 (0.82, 0.90)	0.48 (0.46, 0.50)	0.22 (0.20, 0.24)	0.96 (0.94, 0.97)	0.67 (0.27, 0.73)	6.1 (4.3, 8.5)
NEWS2 ≥ 4 (Youden’s optimal cut-off)	0.76 (0.71, 0.80)	0.62 (0.60, 0.65)	0.25 (0.22, 0.28)	0.94 (0.92, 0.95)	0.69 (0.24, 0.73)	5.1 (3.9, 6.7)
NEWS2 ≥ 5	0.64 (0.59, 0.69)	0.74 (0.72, 0.76)	0.29 (0.26, 0.33)	0.93 (0.91, 0.94)	0.69 (0.17, 0.81)	5.0 (3.9, 6.4)

* Abbreviations: PE = pulmonary embolism PPV = positive predictive value, NPV = negative predictive value, AUC = area under the curve, OR = odds ratio

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